Here's a big Guild Wars irritation: when you go out of a town into the world, and do a quest, and the last step of the quest is to return the people to the town. If you mistakenly walk inside the town before the quest "completes" you lose all your progress and have to start over. (one time we sat around for like a minute before it completed, last night the people to return were following me and djedi was a little ahead and so entered the city before they got to the right spot) This sucks, and I can think of two or three ways to fix it off the top of my head.
I cannot stop being excited about Smash Bros! March 9th can't come soon enough!